Results & Side Effects

Feel the touch of calm skin Not the discomfort of eczema

mild to moderate eczema (atopic dermatitis) for age 6+

Not an actual patient. Symptoms illustrated.

ZORYVE (roflumilast) cream 0.15%

ZORYVE (roflumilast) cream 0.15%

ZORYVE rhymes with “BELIEVE”

ZORYVE was tested as a once-daily, stand-alone treatment for 4 weeks in 2 clinical studies involving 1,337 people ages 6 and older with mild to moderate eczema. 884 people used ZORYVE, and 453 people used an inactive cream (a cream not containing the active ingredient).

Clear or Almost Clear skin*

31% of people using ZORYVE had Clear or Almost Clear skin in 4 weeks vs 14% of people using inactive cream*

Fast itch relief

32% of 542 people using ZORYVE felt itch relief in 4 weeks vs 17% of 271 people using inactive cream

*People who had Clear or Almost Clear skin and a 2-point improvement on a 5-point severity scale. 0 = Clear, 1 = Almost Clear, 2 = Mild, 3 = Moderate, 4 = Severe.

Most Common Side Effects

Additional Results

These assessments were exploratory endpoints, which means these findings can help describe patterns but aren’t meant for definitive conclusions. Individual results may vary.

Eczema Disease Improvement

of people had some level of disease improvement with ZORYVE in 4 weeks vs 77% of people using inactive cream.

Itch After Application

Some people using ZORYVE felt less itch within 24 hours after their first application.

Results you can see and feel anywhere on the skin

Actual clinical trial patients. Results may vary.

Inside Elbow

12 YEAR OLD

Day 1

Inside elbow of clinical trial patient before starting treatment with ZORYVE

Inside elbow of clinical trial patient 1 week after ZORYVE treatment

Inside elbow of clinical trial patient 4 weeks after ZORYVE treatment

Mouth

9 YEAR OLD

Day 1

Mouth of clinical trial patient before starting treatment with ZORYVE

Mouth of clinical trial patient 1 week after ZORYVE treatment

Mouth of clinical trial patient 4 weeks after ZORYVE treatment

Ankle

65 YEAR OLD

Day 1

Ankle of clinical trial patient before starting treatment with ZORYVE

Ankle of clinical trial patient 1 week after ZORYVE treatment

Ankle of clinical trial patient 4 weeks after ZORYVE treatment

Hand & Inside Wrist

24 YEAR OLD

Day 1

Hand & inside wrist of clinical trial patient before starting treatment with ZORYVE

Hand & inside wrist of clinical trial patient 1 week after ZORYVE treatment

Hand & inside wrist of clinical trial patient 4 weeks after ZORYVE treatment

Hand

11 YEAR OLD

Day 1

Hand of clinical trial patient before starting treatment with ZORYVE

Hand of clinical trial patient 1 week after ZORYVE treatment

Hand of clinical trial patient 4 weeks after ZORYVE treatment

Chest

17 YEAR OLD

Day 1

Chest of clinical trial patient before starting treatment with ZORYVE

Chest of clinical trial patient 1 week after ZORYVE treatment

Chest of clinical trial patient 4 weeks after ZORYVE treatment

Before starting treatment with ZORYVE in the clinical trials, 61% of people previously used topical steroids that did not help or were not the right fit for them.

Does ZORYVE burn or sting?

Low rates of stinging or burning that caused discomfort (1.6%) were reported after first application of ZORYVE
vs 2.0% with inactive cream.

Most common side effects from clinical trials

These are not all the possible side effects of ZORYVE cream. Call your doctor for medical advice about side effects.

ZORYVE is safe and can be used anywhere on the skin affected with eczema and for however long you or your child needs it.

Real ZORYVE 0.15% patient Laney

“ My skin feels calm and ZORYVE has helped me feel much more in control of my symptoms.

Laney, a real ZORYVE cream 0.15% patient

See Real Patient Stories

Results may vary.

Talk with your
dermatology provider

Not sure how to talk about your or your little one's atopic dermatitis? See our helpful Appointment Guide.

Next:
Applying ZORYVE
is as easy as 1-2-3